The enzymatic recycling of polyethylene terephthalate (PET) can be a promising approach to tackle the problem of plastic waste. The thermostability and activity of PET-hydrolyzing enzymes are still insufficient for practical application....
Tadeo Moreno-Chicano Leiah M Carey Danny Axford John H Beale R Bruce Doak Helen M E Duyvesteyn Ali Ebrahim Robert W Henning Diana C F Monteiro Dean A Myles Shigeki Owada Darren A Sherrell Megan L Straw Vukica Šrajer Hiroshi Sugimoto Kensuke Tono Takehiko Tosha Ivo Tews Martin Trebbin Richard W Strange Kevin L Weiss Jonathan A R Worrall Flora Meilleur Robin L Owen Reza A Ghiladi Michael A Hough
IUCrJ 9(Pt 5) 610-624 2022年9月
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that ar...
Samuel L Rose Seiki Baba Hideo Okumura Svetlana V Antonyuk Daisuke Sasaki Tobias M Hedison Muralidharan Shanmugam Derren J Heyes Nigel S Scrutton Takashi Kumasaka Takehiko Tosha Robert R Eady Masaki Yamamoto S Samar Hasnain
Proceedings of the National Academy of Sciences of the United States of America 119(30) e2205664119 2022年7月
Many enzymes utilize redox-coupled centers for performing catalysis where these centers are used to control and regulate the transfer of electrons required for catalysis, whose untimely delivery can lead to a state incapable of binding the substra...
Proceedings of the National Academy of Sciences of the United States of America 119(27) e2123385119 2022年7月
Bacterial pathogens acquire heme from the host hemoglobin as an iron nutrient for their virulence and proliferation in blood. Concurrently, they encounter cytotoxic-free heme that escapes the heme-acquisition process. To overcome this toxicity, ma...
Hirotoshi Matsumura Abayomi S Faponle Peter-Leon Hagedoorn Takehiko Tosha Sam P de Visser Pierre Moënne-Loccoz
Journal of inorganic biochemistry 231 111781-111781 2022年6月
Steady-state kinetics of cytochrome-c dependent denitrifying NO reductases (cNORs) show evidence of substrate inhibition at NO concentrations higher than 10 μM, but the mechanism of inhibition remains unclear. Here, we present low-temperature FTIR...
BIN MOHAMAD JAMALI Muhamad Arif GOPALASINGAM Chai C. JOHNSON Rachel M. MUENCH Stephen P ANTONYUK Svetlana V. HASNAIN Samar S. TOSHA Takehiko MURAMOTO Kazumasa SHIRO Yoshitsugu
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理学研究科