Journal of Cell Science 125(24) 6127-6136 2012年12月
The regulation of lipolysis in adipocytes involves coordinated actions of many lipid droplet (LD)-associated proteins such as perilipin, hormone sensitive lipase (HSL), adipose triglyceride lipase (ATGL), and its activator protein, CGI-58. Here, w...
The Journal of biological chemistry 287(28) 23852-63 2012年7月
Lipid droplets (LDs) are ubiquitous organelles storing neutral lipids, including triacylglycerol (TAG) and cholesterol ester. The properties of LDs vary greatly among tissues, and LD-binding proteins, the perilipin family in particular, play criti...
Hiroyuki Ida Noriyuki Suzusho Osamu Suyari Hideki Yoshida Katsuhito Ohno Fumiko Hirose Masanobu Itoh Masamitsu Yamaguchi
Nucleic Acids Research 37(5) 1423-1437 2009年4月
The DNA replication-related element-binding factor (DREF) regulates cell proliferation-related gene expression in Drosophila. By genetic screening, taking advantage of the rough eye phenotype of transgenic flies that express DREF in the eye discs,...
Biochemical and biophysical research communications 368(3) 563-8 2008年4月
Perilipin is a protein localized on lipid droplet surfaces in adipocytes and steroidogenic cells, playing a central role in regulated lipolysis. Expression of the perilipin gene is markedly induced during adipogenesis. We found that transcription ...
Estrogen receptor-related receptors (ERRs) are orphan members of the nuclear receptor superfamily. A single AGGTCA sequence element preceded by three conserved nucleotides has been identified as a specific recognition motif of ERRs. Here we perfor...
E Kwon Y Hayashi K Otsuki F Hirose Y Nishida MA Yoo M Yamaguchi
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1679(3) 256-262 2004年9月
Here we show that Armadillo and Pangolin (dTCF), downstream effectors of the Wingless (Wg) signal transduction pathway, activate transcription of the important DNA replication-related genes encoding Drosophila proliferating cell nuclear antigen (P...
大学本部
理学研究科