Biochimica et biophysica acta 1679(3) 256-62 2004年9月
Here we show that Armadillo and Pangolin (dTCF), downstream effectors of the Wingless (Wg) signal transduction pathway, activate transcription of the important DNA replication-related genes encoding Drosophila proliferating cell nuclear antigen (P...
Masamitsu Yamaguchi   Fumiko Hirose   Yoshihiro H Inoue   Katsuhito Ohno   Hideki Yoshida   Yuko Hayashi   Peter Deak   Akio Matsukage   
Cancer science 95(5) 436-41 2004年5月
Ectopic expression of human p53 in Drosophila eye imaginal disc cells induces apoptosis and results in a rough eye phenotype in the adult flies. We have screened Drosophila stocks to identify mutations that enhance or suppress the p53-induced roug...
Tae-Yeong Choi   So Young Park   Ho-Sung Kang   Jae-Hun Cheong   Han-Do Kim   Bok Luel Lee   Fumiko Hirose   Masamitsu Yamaguchi   Mi-Ae Yoo   
The Biochemical journal 378(Pt 3) 833-8 2004年3月
DREF [DRE (DNA replication-related element) binding factor] is an 80 kDa polypeptide homodimer which plays an important role in regulating cell proliferation-related genes. Both DNA binding and dimer formation activities are associated with residu...
N Ohshima   M Takahashi   F Hirose   
JOURNAL OF BIOLOGICAL CHEMISTRY 278(25) 22928-22938 2003年6月
A human homologue (hDREF/KIAA0785) of Drosophila DREF, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation, was identified by BLAST search. Amino acid sequences corresponding to t...
A DNA replication-related element (DRE)-binding factor (DREF) has been revealed to be an important transcription factor for activating promoters of cell proliferation and differentiation related genes. The amino acid sequences of DREF are conserve...
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1679(3) 256-262 2004年9月
Here we show that Armadillo and Pangolin (dTCF), downstream effectors of the Wingless (Wg) signal transduction pathway, activate transcription of the important DNA replication-related genes encoding Drosophila proliferating cell nuclear antigen (P...