阪口雅郎

研究者氏名	阪口雅郎
	サカグチマサオ
URL	http://www.sci.u-hyogo.ac.jp/life/biochem1/index-j.html
所属	兵庫県立大学
部署	大学院理学研究科・生命科学専攻・生体物質化学Ⅰ分野
職名	教授
学位	理学博士
J-Global ID	200901067109012233

プロフィール

真核細胞のオルガネラ膜形成機構を研究。特に、膜タンパク質のオルガネラ標的化、膜組み込みと構造形成の分子機構に焦点をあてている。

研究キーワード

細胞生物学 ,構造生物化学 ,分子生物学

研究分野

ライフサイエンス / 細胞生物学 /
ライフサイエンス / 機能生物化学 /

学歴

1986年

大阪大学理学研究科生化学

1981年

埼玉大学理学部生化学

受賞

1995年

日本生化学会奨励賞

論文

<123 4 5 >

Stability and flexibility of marginally hydrophobic-segment stalling at the endoplasmic reticulum translocon

Yuichiro Kida Yudai Ishihara Hidenobu Fujita Yukiko Onishi Masao Sakaguchi

MOLECULAR BIOLOGY OF THE CELL 27(6) 930-940 2016年3月 [査読有り]

Many membrane proteins are integrated into the endoplasmic reticulum membrane through the protein-conducting channel, the translocon. Transmembrane segments with insufficient hydrophobicity for membrane integration are frequently found in multispa...

A Few Positively Charged Residues Slow Movement of a Polypeptide Chain across the Endoplasmic Reticulum Membrane

Marifu Yamagishi Yukiko Onishi Shotaro Yoshimura Hidenobu Fujita Kenta Imai Yuichiro Kida Masao Sakaguchi

BIOCHEMISTRY 53(33) 5375-5383 2014年8月 [査読有り]

Many polypeptide chains are translocated across and integrated into the endoplasmic reticulum membrane through protein-conducting channels. During the process, amino acid sequences of translocating polypeptide chains are scanned by the channels an...

Involvement of a di-leucine motif in targeting of ABCC1 to the basolateral plasma membrane of polarized epithelial cells

Yoshikazu Emi Yasue Harada Masao Sakaguchi

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 441(1) 89-95 2013年11月 [査読有り]

Localization of ATP-binding cassette transporter isoform Cl (ABCC1) to the basolateral membrane of polarized cells is crucial for export of a variety of cellular metabolites; however, the mechanism regulating basolateral targeting of the transport...

Membrane translocation of lumenal domains of membrane proteins powered by downstream transmembrane sequences

Takaaki Yabuki Fumiko Morimoto Yuichiro Kida Masao Sakaguchi

Molecular Biology of the Cell 24(19) 3123-3132 2013年10月 [査読有り]

Translocation of the N-terminus of a type I signal anchor (SA-I) sequence across the endoplasmic reticulum membrane can be arrested by tagging with a streptavidin-binding peptide tag (SBP tag) and trapping by streptavidin. In the present study, we...

Stop-and-Move of a Marginally Hydrophobic Segment Translocating across the Endoplasmic Reticulum Membrane

Yukiko Onishi Marifu Yamagishi Kenta Imai Hidenobu Fujita Yuichiro Kida Masao Sakaguchi

JOURNAL OF MOLECULAR BIOLOGY 425(17) 3205-3216 2013年9月 [査読有り]

Many membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane via the protein-conducting channel, the so-called translocon. The hydrophobic transmembrane segment of the translocating nascent polypeptide chain stop...