Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 38(2) 235-239 2022年2月
This paper reports a superiority of the asymmetric electric field formed in the rectangle microwell array for the electrofusion of splenocytes and myeloma cells with different diameters. The upper substrate with microband electrodes was mounted on...
To develop efficient applications of monoclonal antibodies for therapeutic purposes, stereospecific recognition of the target antigens is needed. DNA immunization is one of the best methods for sensitizing B lymphocytes that can produce conformati...
International immunopharmacology 98 107872-107872 2021年9月 [査読有り]
It is quite difficult to generate monoclonal antibodies that recognize the three-dimensional structures of the antigens of interest. To address this limitation, we developed a new hybridoma technology termed "optimized stereospecific targeting (SS...
Journal of immunological methods 484-485 112813-112813 2020年
High priority stereospecific targeting (SST) featuring selective production of conformation-specific monoclonal antibodies was directed against a native receptor, EphA2 (ephrin type-A receptor 2). A critical point for this technology is selection ...
Kanta Tsumoto Yushi Isozaki Hisanori Yagami Masahiro Tomita
Immunotherapy 11(2) 119-127 2019年2月
Attention to therapeutic monoclonal antibodies has been dramatically increasing year by year. Their highly specific targeting of antigens can provide very effective medical treatment, and the advent of molecular-targeting medicine is allowing deve...
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