PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106(52) 22329-22334 2009年12月 [査読有り]
Despite long-standing interest, the molecular mechanisms underlying the establishment of anterior- posterior (AP) polarity remain among the unsolved mysteries in metazoans. In the planarians (a family of flatworms), canonical Wnt/beta-catenin sign...
More than 100 years ago, early workers realized that planarians offer an excellent system for regeneration studies. Another unique aspect of planarians is that they occupy an interesting phylogenetic position with respect to the nervous system in ...
Nishimura, K Kitamura, Y Inoue, T Umesono, Y Yoshimoto, K Taniguchi, T Agata, K
Neurochem Int 53(6-8) 184-192 2008年12月 [査読有り]
The planarian Dugesia japonica has a relatively well-organized central nervous system (CNS) consisting of a brain and ventral nerve cords (VNCs), and can completely regenerate it CNS utilizing pluripotent stem cells present in the mesenchymal spac...
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 363(1500) 2071-2078 2008年6月 [査読有り]
How can planarians regenerate their brain? Recently we have identified many genes critical for this process. Brain regeneration can be divided into five steps: (1) anterior blastema formation, (2) brain rudiment formation, (3) pattern formation, (...
Methods in molecular biology (Clifton, N.J.) 1487 303-315 2017年
Planarians are an ideal model in which to study stem cell-based regeneration. After amputation, planarian pluripotent stem cells surrounding the wound proliferate to produce the regenerative blastema, in which they differentiate into the missing t...
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理学研究科