Nobuhiko EMI

(恵美宣彦)

Profile Information

Affiliation: Fujita Health University

Degree: -

J-GLOBAL ID: 200901075041547411
researchmap Member ID: 1000251702

Research Interests

Research Areas

Research History

Feb, 2015 - Present

Deputy Director, University Hospital, Fujita Health University
Apr, 2008 - Present

Professor, Dep. of Internal Medicine, Fujita Health University

Education

Apr, 1989 - Mar, 2000

Center for molecular Genetics, Dept. of Pediatrics, University of California, SanDiego
Apr, 1983 - Mar, 1987

Graduated School of Medicine, Dept. of Medicine, Nagoya Universitya
Apr, 1975 - Mar, 1981

Dept. of Medicine, Nagoya University

Papers

113

The prognostic significance of EBV DNA load and EBER status in diagnostic specimens from diffuse large B-cell lymphoma patients

Akinao Okamoto, Masamitsu Yanada, Yoko Inaguma, Masutaka Tokuda, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Shuichi Mizuta, Yoshiki Akatsuka, Tetsushi Yoshikawa, Yoshikazu Mizoguchi, Shigeo Nakamura, Masataka Okamoto, Nobuhiko Emi

Hematological Oncology, 35(1) 87-93, Mar 1, 2017 Peer-reviewed
ETV6-LPXN fusion transcript generated by t(11;12)(q12.1;p13) in a patient with relapsing acute myeloid leukemia with NUP98-HOXA9

Akihiro Abe, Yukiya Yamamoto, Sachiko Iba, Tadaharu Kanie, Akinao Okamoto, Masutaka Tokuda, Yoko Inaguma, Masamitsu Yanada, Satoko Morishima, Shuichi Mizuta, Yoshiki Akatsuka, Masataka Okamoto, Toshiki Kameyama, Akila Mayeda, Nobuhiko Emi

Genes Chromosomes and Cancer, 55(3) 242-250, Mar 1, 2016 Peer-reviewed
Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia

Yoko Inaguma, Yoshiki Akatsuka, Kohei Hosokawa, Hiroyuki Maruyama, Akinao Okamoto, Takamasa Katagiri, Keiko Shiraishi, Yuko Murayama, Sachiko Tsuzuki-Iba, Yuuki Mizutani, Chikako Nishii, Naoki Yamamoto, Ayako Demachi-Okamura, Kiyotaka Kuzushima, Seishi Ogawa, Nobuhiko Emi, Shinji Nakao

BRITISH JOURNAL OF HAEMATOLOGY, 172(1) 131-134, Jan, 2016 Peer-reviewed
NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214

Akihiro Abe, Yukiya Yamamoto, Sachiko Iba, Akinao Okamoto, Masutaka Tokuda, Yoko Inaguma, Masamitsu Yanada, Satoko Morishima, Tadaharu Kanie, Motohiro Tsuzuki, Yoshiki Akatsuka, Shuichi Mizuta, Masataka Okamoto, Toshiki Kameyama, Akila Mayeda, Nobuhiko Emi

Cytogenetic and Genome Research, 146(4) 279-284, Dec 1, 2015 Peer-reviewed
Prognostic significance of Epstein-Barr virus DNA detection in pretreatment serum in diffuse large B-cell lymphoma

Akinao Okamoto, Masamitsu Yanada, Hiroki Miura, Yoko Inaguma, Masutaka Tokuda, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Shuichi Mizuta, Yoshiki Akatsuka, Tetsushi Yoshikawa, Yoshikazu Mizoguchi, Shigeo Nakamura, Masataka Okamoto, Nobuhiko Emi

Cancer Science, 106(11) 1576-1581, Nov 1, 2015 Peer-reviewed

Misc.

最重症再生不良性貧血の一例

水谷有希, 佐藤聖子, 大澤道子, 西井智香子, 松浦秀哲, 杉浦縁, 稲熊容子, 赤塚美樹, 恵美宣彦

日本検査血液学会雑誌, 16(学術集会) S112-S112, Jun, 2015
藤田保健衛生大学病院輸血タスクフォースの取り組み

松浦秀哲, 水田秀一, 杉浦縁, 橋本さや香, 荒川章子, 村山元秀, 高木里枝, 関谷佳代, 石神泰子, 岡松幸代, 大川千春, 酒井敏江, 赤塚美樹, 恵美宣彦

日本輸血細胞治療学会誌, 61(2) 269-269, Apr, 2015
血小板輸血効果が得られない新生児血小板減少症への対応

松浦秀哲, 杉浦縁, 倉橋美千代, 荒川章子, 村山元秀, 村松知佳, 加藤友理, 沼尻茜, 水田秀一, 恵美宣彦

日本輸血細胞治療学会誌, 61(2) 347-347, Apr, 2015
血液悪性腫瘍を発症した患者の微量元素、ビタミンの血中濃度の検討

徳田倍将, 稲熊容子, 蟹江匡治, 山本幸也, 柳田正光, 水田秀一, 赤塚美樹, 岡本昌隆, 恵美宣彦

日本内科学会雑誌, 104(Suppl.) 176-176, Feb, 2015
びまん性大細胞型B細胞リンパ腫における免疫表現型による予後因子の検討リツキシマブ併用群と非併用群の比較検討

新津望, 高橋直樹, 稲熊容子, 田丸淳一, 恵美宣彦, 郡美佳, 酒井純, 麻生範雄, 岡本昌隆

日本内科学会雑誌, 104(Suppl.) 227-227, Feb, 2015
当院における輸血副作用発生状況の検討

加藤友理, 松浦秀哲, 永田梨奈, 沼尻茜, 村松知佳, 村山元秀, 荒川章子, 倉橋美千代, 杉浦縁, 岡本晃直, 水田秀一, 赤塚美樹, 恵美宣彦

日本輸血細胞治療学会誌, 61(1) 42-42, Feb, 2015
末梢血幹細胞採取量予測に関する検討

杉浦縁, 松浦秀哲, 水田秀一, 永田梨奈, 沼尻茜, 加藤友理, 村松知佳, 村山元秀, 荒川章子, 倉橋美千代, 岡本晃直, 赤塚美樹, 恵美宣彦

日本輸血細胞治療学会誌, 61(1) 45-45, Feb, 2015
私のこの一枚症例報告 HLH軽快後にB細胞リンパ腫の診断に至った1例

稲熊容子, 赤塚美樹, 岡本昌隆, 恵美宣彦

血液フロンティア, 25(2) 155-160, Jan, 2015
異なった親和性をもつHLA-A2拘束性マイナー抗原HA-1Hを特異的CAR-T細胞の機能解析

赤塚美樹, 赤堀泰, 稲熊容子, 西村泰治, 岡村文子, 葛島清隆, 恵美宣彦

日本がん免疫学会総会プログラム・抄録集, 18回 125-125, Jun, 2014
急速大量輸血を想定したカリウム吸着フィルターの検討

村松知佳, 学病院, 輸血部, 松浦秀哲, 磯貝聡衣, 杉浦縁, 沼尻茜, 加藤友理, 村山元秀, 荒川章子, 倉橋美千代, 高須賀広久, 赤塚美樹, 水田秀一, 恵美宣彦

日本輸血細胞治療学会誌(1881-3011), 60(2) 305, Apr, 2014
HLA-A2に提示されたマイナー抗原HA-1認識抗体の開発と応用(Construction and molecular characterization of a single chain antibody specific for HA-1 minor H antigen)

赤塚美樹, 岡村文子, 山本幸也, 西村泰治, 高橋利忠, 葛島清隆, 恵美宣彦

日本癌学会総会記事, 72回 353-353, Oct, 2013
The demarcation between younger and older acute myeloid leukemia patients: A pooled analysis of 3 prospective studies

Masamitsu Yanada, Shigeki Ohtake, Shuichi Miyawaki, Hisashi Sakamaki, Toru Sakura, Tomoya Maeda, Koichi Miyamura, Norio Asou, Iekuni Oh, Junichi Miyatake, Hiroyuki Kanbayashi, Jin Takeuchi, Masatomo Takahashi, Nobuaki Dobashi, Hitoshi Kiyoi, Yasushi Miyazaki, Nobuhiko Emi, Yukio Kobayashi, Ryuzo Ohno, Tomoki Naoe

Cancer, 119(18) 3326-3333, Sep 15, 2013
Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes

Yasunori Ueda, Chisato Mizutani, Yasuhito Nannya, Mineo Kurokawa, Sumiko Kobayashi, Jin Takeuchi, Hideto Tamura, Kiyoyuki Ogata, Kazuo Dan, Hirohiko Shibayama, Yuzuru Kanakura, Keiko Niimi, Ko Sasaki, Masato Watanabe, Nobuhiko Emi, Masanao Teramura, Toshiko Motoji, Michiko Kida, Kensuke Usuki, Satoru Takada, Toru Sakura, Yoshikazu Ito, Kazuma Ohyashiki, Hiroyasu Ogawa, Takahiro Suzuki, Keiya Ozawa, Kiyotoshi Imai, Masaharu Kasai, Tomoko Hata, Yasushi Miyazaki, Yasuyoshi Morita, Akihisa Kanamaru, Akira Matsuda, Kaoru Tohyama, Daisuke Koga, Hiroya Tamaki, Kinuko Mitani, Tomoki Naoe, Haruo Sugiyama, Fumimaro Takaku

LEUKEMIA & LYMPHOMA, 54(7) 1450-1458, Jul, 2013
Randomized controlled trial comparing ciprofloxacin and cefepime in febrile neutropenic patients with hematological malignancies

Takahiko Yasuda, Ritsuro Suzuki, Yuichi Ishikawa, Seitaro Terakura, Yoshihiro Inamoto, Masamitsu Yanada, Hirokazu Nagai, Yukiyasu Ozawa, Kazutaka Ozeki, Yoshiko Atsuta, Nobuhiko Emi, Tomoki Naoe

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 17(6) E385-E390, Jun, 2013
Effect of related donor availability on outcome of AML in the context of related and unrelated hematopoietic cell transplantation

M. Yanada, S. Kurosawa, T. Yamaguchi, N. Uchida, S. Miyawaki, H. Kanamori, K. Usuki, T. Kobayashi, M. Watanabe, K. Nagafuji, S. Yano, Y. Nawa, J. Tomiyama, H. Tashiro, Y. Nakamura, S. Fujisawa, F. Kimura, N. Emi, I. Miura, T. Fukuda

BONE MARROW TRANSPLANTATION, 48(3) 390-395, Mar, 2013
Differences in outcome for consecutive patients with diffuse large B-cell lymphoma before and after the advent of rituximab: A single-center experience

Akinao Okamoto, Masamitsu Yanada, Yoko Inaguma, Masutaka Tokuda, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Motohiro Tsuzuki, Yoshiki Akatsuka, Shuichi Mizuta, Masataka Okamoto, Nobuhiko Emi

Hematology, 18(2) 74-80, Mar, 2013
Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia

Masamitsu Yanada, Japan Adult Leukemia Study Group, Motohiro Tsuzuki, Hiroyuki Fujita, Katsumichi Fujimaki, Shin Fujisawa, Kazutaka Sunami, Masafumi Taniwaki, Akira Ohwada, Kosuke Tsuboi, Akio Maeda, Akihiro Takeshita, Shigeki Ohtake, Yasushi Miyazaki, Yoshiko Atsuta, Yukio Kobayashi, Tomoki Naoe, Nobuhiko Emi

Blood, 121(16) 3095-3102, 2013
【血液の悪性造血腫瘍】治療最新のポイント成人白血病

恵美宣彦

現代医学(0433-3047), 60(2) 245-249, Dec, 2012
Development of quantitative RT-PCR assays for detection of three classes of HHV-6B gene transcripts

Masaru Ihira, Yoshihiko Enomoto, Yoshiki Kawamura, Hidetaka Nakai, Ken Sugata, Yoshizo Asano, Motohiro Tsuzuki, Nobuhiko Emi, Tatsunori Goto, Koichi Miyamura, Kimikazu Matsumoto, Koji Kato, Yoshiyuki Takahashi, Seiji Kojima, Tetsushi Yoshikawa

JOURNAL OF MEDICAL VIROLOGY, 84(9) 1388-1395, Sep, 2012
造血器腫瘍学-基礎と臨床の最新研究動向-】骨髄系腫瘍の臨床急性前骨髄球性白血病再発急性前骨髄球性白血病の治療

恵美宣彦

日本臨床(0047-1852), 70(2) 420-424, Apr, 2012
Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling

Yukiya Yamamoto, Sachiko Tsuzuki, Yasushi Akahori, Yoshinori Ukai, Mariko Sumitomo, Yuko Murayama, Kiyoko Yamamoto, Youko Inaguma, Masutaka Tokuda, Akihiro Abe, Yoshiki Akatsuka, Nobuhiko Emi, Yoshikazu Kurosawa

Cancer Science, 103(2) 350-359, Feb, 2012
Mismatched human leukocyte antigen class II-restricted CD8(+) cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation

Tomoya Hirosawa, Hiroki Torikai, Mayumi Yanagisawa, Michi Kamei, Nobuhiko Imahashi, Ayako Demachi-Okamura, Miyoko Tanimoto, Keiko Shiraishi, Mamoru Ito, Koichi Miyamura, Kiyosumi Shibata, Fumitaka Kikkawa, Yasuo Morishima, Toshitada Takahashi, Nobuhiko Emi, Kiyotaka Kuzushima, Yoshiki Akatsuka

CANCER SCIENCE, 102(7) 1281-1286, Jul, 2011
Agaritine from Agaricus blazei Murrill induces apoptosis in the leukemic cell line U937

Hidehiko Akiyama, Masahiro Endo, Taei Matsui, Itsurou Katsuda, Nobuhiko Emi, Yasuko Kawamoto, Takaaki Koike, Hidehiko Beppu

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1810(5) 519-525, May, 2011
BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia

Yukiya Yamamoto, Sachiko Tsuzuki, Motohiro Tsuzuki, Kousuke Handa, Yoko Inaguma, Nobuhiko Emi

Blood, 116(20) 4274-4283, Nov 18, 2010
Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: A report from the BINGO study

Yuichi Ishikawa, Hitoshi Kiyoi, Keisuke Watanabe, Koichi Miyamura, Yasuyuki Nakano, Kunio Kitamura, Akio Kohno, Isamu Sugiura, Toshiya Yokozawa, Akitoshi Hanamura, Kazuhito Yamamoto, Hiroatsu Iida, Nobuhiko Emi, Ritsuro Suzuki, Kazunori Ohnishi, Tomoki Naoe

CANCER SCIENCE, 101(10) 2186-2192, Oct, 2010
Evaluation of Blood Purification and Bortezomib Plus Dexamethasone Therapy for the Treatment of Acute Renal Failure Due to Myeloma Cast Nephropathy

Midori Hasegawa, Fumiko Kondo, Koichiro Yamamoto, Kazutaka Murakami, Makoto Tomita, Kunihiro Nabeshima, Shigeru Nakai, Masao Kato, Atsushi Ohashi, Jiro Arai, Yoshiyuki Hiki, Junichi Ishii, Nobuhiko Emi, Satoshi Sugiyama, Yukio Yuzawa

THERAPEUTIC APHERESIS AND DIALYSIS, 14(5) 451-456, Oct, 2010
Heat denaturation increases the sensitivity of the cytomegalovirus loop-mediated isothermal amplification method

Ryota Suzuki, Masaru Ihira, Yoshihiko Enomoto, Hiroaki Yano, Fumio Maruyama, Nobuhiko Emi, Yoshizo Asano, Tetsushi Yoshikawa

MICROBIOLOGY AND IMMUNOLOGY, 54(8) 466-470, Aug, 2010
BCR-ABL-independent and RAS/MAPK pathway-dependent form of imatinib resistance in Ph-positive acute lymphoblastic leukemia cell line with activation of EphB4

Momoko Suzuki, Akihiro Abe, Shizuka Imagama, Yuka Nomura, Ryohei Tanizaki, Yosuke Minami, Fumihiko Hayakawa, Yoshie Ito, Akira Katsumi, Kazuhito Yamamoto, Nobuhiko Emi, Hitoshi Kiyoi, Tomoki Naoe

EUROPEAN JOURNAL OF HAEMATOLOGY, 84(3) 229-238, Mar, 2010
Allogeneic stem cell transplantation versus chemotherapy as post-remission therapy for intermediate or poor risk adult acute myeloid leukemia: results of the JALSG AML97 study

Hisashi Sakamaki, Shuichi Miyawaki, Shigeki Ohtake, Nobuhiko Emi, Fumiharu Yagasaki, Kinuko Mitani, Shin Matsuda, Yuji Kishimoto, Yasushi Miyazaki, Norio Asou, Masatomo Takahashi, Yoshiaki Ogawa, Sumihisa Honda, Ryuzo Ohno

INTERNATIONAL JOURNAL OF HEMATOLOGY, 91(2) 284-292, Mar, 2010
Rituximab併用化学療法における液性免疫能の変化および帯状疱疹(H.zoster)の発症頻度について

伊藤佳織, 岡本昌隆, 丸山文夫, 半田幸助, 山本幸也, 渡邊正人, 都築基弘, 水田秀一, 熊澤里美, 太田秀基, 中野一子, 恵美宣彦

癌と化学療法, 37(1) 99-102, Jan, 2010
Factor VII deficiency: a double heterozygote of an Arg402Stop with a deletion of the C-terminal five amino acids and a Thr359Met

Masataka Okamoto, Itsuro Katsuda, Yasuna Ohshika, Fumio Maruyama, Kohji Ezaki, Nobuhiko Emi, Yoshikazu Ichihara

EUROPEAN JOURNAL OF HAEMATOLOGY, 82(5) 405-407, May, 2009
Successful pregnancy in a patient with chronic myeloid leukemia under treatment with imatinib

Motohiro Tsuzuki, Youko Inaguma, Kousuke Handa, Akio Hasegawa, Yukiya Yamamoto, Masato Watanabe, Syuichi Mizuta, Fumio Maruyama, Masataka Okamoto, Nobuhiko Emi

Internal Medicine, 48(16) 1433-1435, 2009
Effect of transferrin as a ligand of pH-sensitive fusogenic liposome-lipoplex hybrid complexes

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Nobuhiko Emi, Kenji Kono

BIOCONJUGATE CHEMISTRY, 19(8) 1588-1595, Aug, 2008
Generation of highly potent nonviral gene vectors by complexation of lipoplexes and transferrin-bearing fusogenic polymer-modified liposomes in aqueous glucose solution

Naoki Sakaguchi, Chie Kojima, Atsushi Harada, Kazunori Koiwai, Kazuhiro Shimizu, Nobuhiko Emi, Kenji Kono

BIOMATERIALS, 29(9) 1262-1272, Mar, 2008
Clinical characteristics and outcomes in patients with t(8;21) acute myeloid leukemia in Japan

H. Narimatsu, T. Yokozawa, H. Iida, M. Tsuzuki, M. Hayakawa, T. Takeo, M. Iino, T. Ichihashi, C. Kato, A. Sawamoto, H. Sao, M. Yanada, N. Emi, H. Kiyoi, T. Yamaguchi, T. Naoe, R. Suzuki, I. Sugiura

LEUKEMIA, 22(2) 428-432, Feb, 2008
Chronic myeloid leukemia following chemotherapy with 5′-deoxy-5-fluorouridine for gastric cancer

Motohiro Tsuzuki, Kousuke Handa, Kiyoko Yamamoto, Akio Hasegawa, Yukiya Yamamoto, Masato Watanabe, Syuichi Mizuta, Fumio Maruyama, Masataka Okamoto, Nobuhiko Emi, Kohji Ezaki

Internal Medicine, 47(19) 1739-1741, 2008

Presentations

27-O4PM-05 びまん性大細胞型B細胞リンパ腫患者におけるR-CHOP療法開始後のヘルペスウイルス感染症発症と免疫指標との関連に関する検討(感染症治療・予防,優秀演題候補セッション7,新時代を拓く医療薬学フロンティア)

伊藤佳織, 岡本昌隆, 安藤舞子, 辻井奈保, 屋良枝利, 岡本晃直, 稲熊容子, 徳田倍将, 加藤さや香, 牧原俊康, 赤塚美樹, 恵美宣彦, 山田成樹

日本医療薬学会年会講演要旨集, Aug 25, 2014
27-O2PM-17 rasburicaseの有効性と安全性に関する検討(有害事象・副作用3,一般演題(口頭),新時代を拓く医療薬学フロンティア)

安藤舞子, 岡本昌隆, 伊藤佳織, 辻井奈保, 屋良枝利, 岡本晃直, 稲熊容子, 徳田倍将, 蟹江匡治, 加藤さや香, 牧原俊康, 赤塚美樹, 恵美宣彦, 山田成樹

日本医療薬学会年会講演要旨集, Aug 25, 2014
Calcium Phosphate and Aluminum Hydroxide as Non-Virus Gene Carrior: the Morphology of DNA-salt Complex and the Effects It on DNA Transfection

Matsuzawa Yukiko, Emi Nobuhiko, Kanbe Toshio

Chemical engineering, 2003

The morphology of complexes between DNA and the inorganic salts calcium phosphate and aluminum hydroxide, which function as DNA carriers, was examined. Calcium phosphate is a conventional DNA carrier for anchored cells and is known to condense and precipitate DNA molecules. At higher concentrations of DNA, the size of the DNA-calcium phosphate complex increased. However, mono-dispersed and condensed particles were more prevalent at increasing concentrations of DNA. DNA uptake was more efficient in the particles compared to the aggregates. We also investigated the complex between DNA and aluminum hydroxide, which already used as an adjuvant. The extent of DNA uptake was also affected by the size of the DNA-aluminum hydroxide complex. The dramatic changes in DNA conformation are discussed in relation to the efficiency of gene transfection.
自由1 遺伝子導入マテリアルの安全性について(VI 共同利用研究 2.研究成果)

恵美宣彦

霊長類研究所年報, Aug 27, 2002
W-5-4 同種末梢血幹細胞ドナー登録センターの対応

山田剛久, 土肥博雄, 中畑龍俊, 今村雅寛, 河敬世, 恵美宣彦, 山本一仁, 小寺良尚

日本アフェレシス学会雑誌, Jun 14, 2002

Professional Memberships

教育内容・方法の工夫（授業評価等を含む）

件名（英語）

M３授業、M5ポリクリ授業、教授回診などを通じて血液内科に興味を持たせるように工夫をしています。

開始年月日（英語）

2009

終了年月日（英語）

2013

概要（英語）

M3:血液内科学総論など血液学の授業を通じて、造血組織の理解と機能を説明する。M5では、小グループでの討論会、回診を通じて、血液疾患の治療のメカニズム、分指標的両方に関して説明をする。

作成した教科書、教材、参考書

件名（英語）

レジメンの配布、PPTの作成，試験問題の作成

概要（英語）

授業用の資料作成をして、学生にわかりやすい記載方法を検討している。学生の興味を持つように、血液内科のホームページを作成し、定期的に更新をしている。卒業試験、総合試験を理解度のわかるようなレベルで作成をしている。

その他教育活動上特記すべき事項

件名（英語）

指導教授として担当学生の個別指導

概要（英語）

定期的に指導担当学生に面接をして勉強の進捗、悩みなどの相談を受ける。将来の医師像の話し合い、ご家庭の希望などをお聞きして、ご本人にあった将来像を提案している。

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